The miracles of science™

Select Industry


DuPont Biotechnology website

Herculex® RW Literature References


  1. Adang, M. J., Firoozabady, E., Klein, J., DeBoer, D., Sekar, V., Kemp, J.D., Murray, E.,Rocheleau, T.A., Rashka, K., Staffeld, C., Stock, C., Sutton, D., and Merlo, D. J. 1987. Expression of a Bacillus thuringiensis insecticidal crystal protein gene in tobacco plants. In: Molecular Strategies for Crop Protection, C. Arntzen and C. Ryan, (Ed. Alan R. Liss) Inc. New York  p. 345-353.
  2. An, G., Mitra, A., Choi, H.K., Costa, M., An, K., Thornburg, R.W., and Ryan, C.A.  1989.  Functional analysis of the 3’ control region of the potato wound-inducible protease inhibitor II gene.  Plant Cell 1:  115-122.
  3. Astwood, J.D., Leach, J.N., and Fuchs, R.L. 1996. Stability of food allergens to digestion in vitro. Nat. Biotechnol. 14:1269.
  4. Baker, H.G. 1974.  The Evolution of Weeds.  Ann. Rev. of Ecol. and Syst. 5:1-24.
  5. Batista, R., Nunes, B., Carmo, M., Cardoso, C., Jose, H.S., de Almeida, A.B., Manique, A., Bento, L., Ricardo, C.P., and Oliveira, M.M. 2005. Lack of detectable allergenicity of transgenic maize and soya samples. J. Allergy Clin. Immunol., 116: 403-410.
  6. Betz, F.S., Hammond, B.G., and Fuchs, R.L. 2000. Safety and advantages of Bacillus thuringiensis-protected plants to control insect pests.  Reg. Toxicol. Pharmacol. 32:156-173.
  7. Canadian Food Inspection Agency. 1994.  Regulatory Directive Dir 94-11: The Biology of Zea mays L. (Corn/Maize).  CFIA, Plant Products Division, Plant Biotechnology Office, Ottawa.
  8. Christensen, A.H., Sharrock, R.A., and Quail, P.H. 1992. Maize polyubiquitin genes: Structure, thermal perturbation of expression and transcript splicing, and promoter activity following transfer to protoplasts by electroporation. Plant Mol. Biol. 18:675-689.
  9. Codex Alimentarius Commission, Alinorm 03/34: Joint FAO/WHO Food Standard Programme, Codex Alimentarius Commission, Twenty-Fifth Session, Rome, Italy, 30 June-5 July, 2003. Appendix III, Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants, and Appendix IV, Annex on the assessment of possible allergenicity. p. 47-60.
  10. Day, P. 1992. The Biology of Plant Proteins. Crit. Rev. Food Sci. Nutr. 36:39-47.
  11. De Block, M., D'Halluin,-K.; Botterman,-J., and Leemans, J. 1988. The use of phosphinothricin resistance as a selectable marker in tobacco protoplast transformation. Curr. Plant Sci. Biotechnol. Agric. Dordrecht, Kluwer Academic Publishers. p. 389-390.
  12. FAO/WHO.  2001. Evaluation of allergenicity of genetically modified foods.  Report of a Joint FAO/WHO Expert Consultation on Allergenicity of Foods Derived from Biotechnology.  January 22-25, 2001. Rome, Italy.
  13. Fu, T.-J., Abbott, U.R., and Hatzos, C. 2002. Digestibility of food allergens and nonallergenic proteins in simulated gasric fluid and simulated intestinal fluid – a comparative study. J. Agric. Food Chem. 50:7154-7160.
  14. Hefle, S.L., Nordlee, J.A., and Taylor, S.L. 1996. Allergenic foods. Crit. Rev. Food  Sci. Nutr. 36:69-89.
  15. Herman, R.A., Schafer, B.W., Korjagin, V.A., and Ernest, A.D.  2003.  Rapid digestion of Cry34Ab1 and Cry35Ab1 in simulated gastric fluid.  J. Agric. Food Chem. 5:6823-6827.
  16. Hertig, C., Rebmann, G., Bull, J., Mauch, F., and Dudler, R. 1991. Sequence and tissue specific expression of a putative peroxidase gene from wheat (Triticum aestivum L.).  Plant Mol. Biol. 16:  171-174.
  17. ILSI (International Life Sciences Institute). 2003.  ILSI Crop Composition Database. www.cropcomposition.org.
  18. Iowa Gold Catalog, 1994. Iowa Department of Agriculture and Land Stewardship. 1993 Catalog.
  19. Jungenheimer, R.W. 1976. Corn. Improvement, seed production, and uses. John Wiley and Sons, New York/London/Sydney/Toronto.
  20. Metcalfe, D.D., Astwood, J.D., Townsend, R., Sampson, H.A., Taylor, S.L., and Fuchs, R.L. 1996. Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit. Rev. Food Sci. Nutr. 36:165-186.
  21. Moellenbeck, D.J., M.L. Peters, J.W. Bing, J.R. Rouse, L.S. Higgins, L. Sims, T. Nevshemal, L. Marshall, R.T. Ellis, P.G. Bystrak, B.A. Lang, J.L. Stewart, K. Kouba, V. Sondag, V. Gustafson, K. Nour, D. Xu, J. Swenson, J. Zhang, T. Czapla, G. Schwab, S. Jayne, B.A. Stockhoff, K. Narva, H.E. Schnepf, S.J. Stelman, C. Poutre, M. Koziel, and N. Duck. 2001. Insecticidal proteins from Bacillus thuringiensis protect corn from corn rootworms. Nature Biotechnology. 19: 668 - 672.
  22. Nap, J.P., Bijvoet, J., and Strikema, W.J. 1992. Biosafety of kanamycin-resistant transgenic plants:  An overview.  Transgenic Crops 1:239-249.
  23. National Center for Food and Agricultural Policy. 2002. Plant Biotechnology: Current and Potential Impact For Improving Pest Management In U.S. Agriculture. An Analysis of 40 Case Studies.
  24. National Center for Food and Agricultural Policy. 2004. Impacts on U.S. Agriculture of Biotechnology-Derived Crops Planted in 2003. An Update on 11 Case studies.
  25. OECD (Organisation for Economic Cooperation and Development). 1999. Series on Harmonisation of Regulatory Oversight in Biotechnology, No 11. Consensus Document on General Information Concerning the Genes and their Enzymes that Confer Tolerance to Phosphinothricin Herbicide. Environment Directorate - Joint Meeting of the chemicals committee and working party on chemicals. ENV/JM/MONO 13.
  26. OECD. 2002. Consensus document on compositional considerations for new varieties of maize (Zea mays):  Key food and feed nutrients, anti-nutrients and secondary plant metabolites.  ENV/JM/MONO 25. 
  27. Pietrzak, M., Shillito, R., Hohn, T., and Potrykus, I. 1986. Expression in plants of two bacterial antibiotic resistance genes after protoplast transformation with a new plant expression vector.  Nucleic Acids Research. Vol. 14. p. 5857-5868.
  28. Redenbaugh, K., Hiatt, W., Martineau, B., Lindemann, J., and Emlay, D. 1994. Aminoglycoside 3’-phosphotransferase II (APH(3’)II):  Review of its safety and use in the production of genetically engineered plants.  Food Biotechnol. 8:137-165.
  29. Sampson, H. A. 1997. Immediate reactions to foods in infants and children. In: Food Allergy:  Adverse Reactions to Foods and Food Additives (eds. Metcalfe, D.D., Sampson, H.A., and Simon, R.A.). Blackwell Science, Cambridge, MA. p. 169-182.
  30. Sims, S.R. and Holden, L.R. 1996. Insect bioassay for determining soil degradation of Bacillus thuringiensis subsp. kurstaki Cry1Ab protein in corn tissue.  Phssio. Chem. Ecol. Vol. 25(3):659-664.
  31. Sjoblad, R.D, McClintock, J.T., and Engler, R. 1992. Toxicological considerations for protein components of biological pesticide products. Regul. Toxicol. Pharmacol. 15:3-9.
  32. Thomas, K. et al. 2004. A multi-laboratory evaluation of a common in vitro pepsin digestion assay protocol used in assessing the safety of novel proteins. Reg. Toxicol. Pharmacol. 39:87-98.
  33. USEPA (United States Environmental Protection Agency). 1997. Terms of Environment. EPA175B97001. USEPA, OC, Washington, DC.
  34. USEP. 2000. Office of Pesticide Programs, Biopesticides and Pollution Prevention Division.  Biopesticides Registration Action Document, Preliminary Risks and Benefits Sections, Bacillus thuringiesis Plant Pesticides. p. 1-17.
  35. USEPA. 2005. SAP Report No. 2005-02.  Meeting Minutes; March 1-2, 2005 FIFRA Scientific Advisory Panel Meeting on Scientific Issues Associated with the Human Health Assessment of the Cry34AB1 Protein. Arlington, VA.
  36. USFDA (United States Food and Drug Administration).  1992. Statement of policy: Foods derived from new plant varieties: Notice. Federal Register 57:22984-23005.
  37. Watson, S.A. 1982. Corn: Amazing Maize: General Properties. In CRC Handbook of Processing and Utilization in Agriculture, Volume II: Part1 Plant Products. I.A.Wolff (ed.) CRC Press Inc., Florida, USA.
  38. Watson, S.A. 1987. Structure and composition. In Corn: Chemistry and Technology, S.A. Watson and P.E. Ransted (eds). American Association of Cereal Chemists, Inc., Minnesota. p. 53-82.
  39. Wehrman, A., Van Vliet, A., Opsomer, C., Botterman, J., and Schulz, A. 1996. The similarities of bar and pat genes products make them equally applicable for plant engineers. Nature Biotech. 14:1274-1278.

Herculex Insect Protection technology by Dow AgroSciences and Pioneer Hi-Bred. ®Herculex is a registered trademark of Dow AgroSciences LLC.
®LIBERTY and LibertyLink are registered trademarks of Bayer AG.