In most cases where herbicide resistant weed biotypes occur, the same herbicide can continue to have utility due to the spectrum of weeds present. To control the herbicide resistant weed, weed scientists recommend the adding another herbicide to the primary herbicide. For example, in fields with glyphosate resistant marestail, glyphosate could be the base treatment that growers augment another herbicide to manage marestail.

Using mixtures of herbicides with different modes of action and overlapping weed spectrums is a common tactic of farmers to manage the evolution of resistant weeds, because it is highly unlikely that weeds will develop resistance to two herbicides with different modes of action if they are used simultaneously. The potential for developing dual herbicide resistance is more likely if the weed is exposed to two herbicides sequentially.

Mixtures of glyphosate with other herbicides can offer a total weed control option for many years to come, provided the crop is resistant. For example, glyphosate and ALS herbicides could be used on biotech corn and soybean that are resistant to both.